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KMID : 0617319980070010205
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Journal of Pharmacetical Sceiences Ewha Womans University
1998 Volume.7 No. 1 p.205 ~ p.210
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SYNTHESES AND ANTIVIRAL ACTIVITIES OF 1,3-DIOXOLANYL-, 1,3-OXATHIOLANYL- AND 1,3-DITHIOLANYLNUCLEOSIDES WITH 2-HYDROXYMETHYL SUBSTITUENTS
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Chun, Moon Woo
Shin, Dae Hong/Moon Hyung Ryong/Lee, Jeewoo/Park, Hokoon/Jeong, Lak Shin
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Abstract
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Novel 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents (1a-4b) were each synthesized with good yields through the condensation of dinucleophiles (oxygen and/or sulfur) with 1,3-dibenzoxy-2-propanone methyl ketal as a key step.
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KEYWORD
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